Cimona Vaughn Hinton, PhD

Cimona-Vaughn-Hinton.jpg

Cimona Vaughn Hinton, PhD

Position(s): Professor ​
Academic Department: Biological Sciences​

 

 

 

Contact: chinton@cau.edu​
Office Location: Thomas Cole Research Center ​​
Office Telephone: 404-880-6337

Education: 

B.S.: Chemistry, University of Maryland Eastern Shore, Princess Anne, MD ​
Ph.D.: Biomedical Sciences (Biochemistry), Meharry Medical College, Nashville, TN ​
Postdoctoral Fellowship: Harvard Medical School & Beth Israel Deaconess Medical Center, Boston, MA

Research Interests:

  • My laboratory broadly focuses on the biochemistry that drives tumor cell motility at both the cellular and molecular levels which translates to metastasis in a human system. We are currently interested in:​
    • (I) tertiary prevention methods of metastasis with cannabinoids; and ​
    • (II) characterizing ROS-bearing tumor immune infiltrates that progress prostate tumors to a mobile phenotype. We primarily investigate CXCR4, CB2, NOX2, NFκB and oxidant signaling mechanisms. 

Publications:

  • ElShaddai Z White, Nakea M Pennant, Jada R Carter, Ohuod Hawsawi, Valerie Odero-Marah, Cimona V Hinton (2020) Serum deprivation initiates adaptation and survival to oxidative stress in prostate cancer cells. Sci Rep, Jul 27;10(1):12505. ​
  • Scarlett, K.A., White, E.Z., Coke, C.J., Coke, Carter, J.R., Bryant, L.K. and Hinton, C.V. (2018) Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration.  Molecular Cancer Research, Apr;16(4):728-739. ​
  • Coke, CJ, Scarlett, KA, Jones, KJ, Davis, A, Chetram, MA, Sandifer, BJ, Marcus, A, and Hinton, CV. (2016) Simultaneous Activation of CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveal a Mechanism for Cancer Cell Metastasis Regulation. Journal of Biological Chemistry 291(19):9991-10005. ​
  • Don-Salu-Hewage AS, Chan SY, McAndrews KM, Chetram MA, Dawson MR, Bethea DA, Hinton CV. (2013) Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells.  PLoS One. 2013;8(2):e57194. ​
  • Jones, K.J., Chetram, M.A., Bethea, D.A., Bryant, L.K., Odero-Marah, V. and Hinton, C.V.  (2013) “Cysteine (C)-X-C Receptor 4 Regulates NADPH Oxidase-2 During Oxidative Stress in Prostate Cancer Cells”.  Cancer Microenvironment: 6(3): 277–288 ​
  • Chetram MA, Bethea DA, Odero-Marah VA, Don-Salu-Hewage AS, Jones KJ, Hinton C.V. (2013) “ROS-Mediated Activation of AKT Induces Apoptosis via pVHL in Prostate Cancer Cells”: Mol Cell Biochem 376: 63-71, PMID: 23315288 ​
  • Smith BA, Neal CL, Chetram M, Vo B, Mezencev R, Hinton C, Odero-Marah VA. (2012) The Phytoalexin Camalexin Mediates Cytotoxicity Towards Aggressive Prostate Cancer Cells via Reactive Oxygen Species”:  J Nat Med Jul; 67 (3):607-18. PMID: 23315288 ​
  • Chetram, M.A., Don-Salu-Hewage, A.S., Hinton, C.V. (2011) “ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells”: Biochemical Biophysical Research Communication: 410 (2):195-200. PMID: 21627959 Selected for the 2014 Virtual Special Issue on ‘Cancer Metastasis’ in BBRC by Dr. Issac P. Witz