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Home News 2015 Clark Atlanta University Researcher's Work on Prostate Cancer Published

Clark Atlanta University Researcher's Work on Prostate Cancer Published

Posted on Wednesday, September 02, 2015


Donna Brock
Larry Calhoun

ATLANTA (Sept 1, 2015) – The prostate cancer research of Bekir Cinar, Ph.D., associate professor in Clark Atlanta University’s (CAU) Department of Biological Sciences and researcher in the Center for Cancer Research and Therapeutic Development (CCRTD), was published in the Sept. 1 issue of Nature Communications.  The article is titled "YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer.”

Cinar said, “Prostate cancer is lethal when emerged as a metastatic, castration-resistant disease.  Our current knowledge into how this lethal disease evolves is limited.  Thus, prostate cancer continues to take the lives of men, especially African-American men, who are at much higher risk of developing prostate cancer than Caucasian men.”

In the current study, Cinar and his colleagues identified a new mechanism that potentially contributes to metastatic, lethal prostate cancer.  This mechanism involves the interaction between androgen receptor (AR), a key promoter ofprostate cancer, and the YAP1 oncogene, a key nuclear effort of the Hippo tumor suppressor pathway.  The study reveals that YAP1-AR interactions are resistant to androgen withdrawal and Enzalutamide, a second-generation AR inhibitor, in castration-resistant prostate cancer (CRPC) cells.  In addition, the Cinar laboratory identified Verteporfin, a pharmacological compound used to treat an age-related ocular degeneration, which is able to block YAP1-AR interactions and to prevent castration- and Enzalutamide-resistant prostate cancer cell growth.  The study suggests that the YAP1-AR signaling axis plays a critical role in the emergence of lethal prostate cancer and is a promising cancer drug target.  Currently, the Cinar laboratory is investigating the detailed mechanism of YAP1-AR interactions and trying to identify downstream targets of YAP1-AR signaling in prostate cancer for therapeutic interventions.

Nature Communications is an online only journal.  Papers are citable via a digital object identifier (DOI) number. The DOI for Cinar’s paper is NCOMMS9126 and can be viewed online at http://www.nature.com/naturecommunications

For information on the CCRTD, visit www.cau.edu/ccrtd.

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Category: Research
Keywords: Prostate Cancer, Bekir Cinar, Clark Atlanta University, Research