Dr. Cimona Hinton
Our laboratory focuses on mechanisms responsible for cancer cell metastasis at both the cellular and molecular levels. In this regard, we currently study the involvement of chemokine pathways that induce motility of cancer cells. The primary objective is to study how the CXCR4/CXCL12 signaling axis may aid in the migration and invasion of foreign tissues under cancerous condition. This system is studied in prostate and breast cancer cells.
Chetram, M.A., Don-Salu-Hewage A.S., and Hinton, C.V. (2011) ROS Enhances CXCR4-mediated Functions through Inactivation of PTEN in Prostate Cancer Cells:Biochemical and Biophysical Research Communications: 410(2):195-200
Chetram, M.A., Odero-Marah, V. and Hinton, C.V. (2010)Loss of PTEN Permits CXCR4-mediated Tumorigenesis through ERK1/2 in Prostate Cancer Cells: Molecular Cancer Research: Jan;9(1):90-102
Chang, M.A., Morgado, M., Warren, C.R., Hinton, C.V., Farruch-Carson, M.C., Delk, N.A. (2013) p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines. Prostate: 74(2):149-63
Jones, K.J., Chetram, M.A., Bethea, D.A., Bryant, L.K., Odero-Marah, V. and Hinton, C.V. (2013) Cysteine (C)-X-C Receptor 4 Regulates NADPH Oxidase-2 During Oxidative Stress in Prostate Cancer Cells. Cancer Microenvironment: 6(3): 277–288
Don-Salu-Hewage, AS, Chan, SY, McAndrews, KA, Chetram, MA, Dawson, MR, Bethea, DA, Hinton, CV (2013) Cysteine (C)-X-C Receptor 4 Undergoes Transportin 1-Dependent Nuclear Localization and Remains Functional at the Nucleus of Metastatic Prostate Cancer Cells: PLoS One 2013;8(2):e57194 PMID: 23468933
Chetram MA, Bethea DA, Odero-Marah VA, Don-Salu-Hewage AS, Jones KJ, Hinton C.V. (2013) ROS-Mediated Activation of AKT Induces Apoptosis via pVHL in Prostate Cancer Cells: Mol Cell Biochem 376: 63-71, PMID: 23315288