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Dr. Cimona Hinton

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Dr. Cimona Hinton
Associate Professor
Department of Biological Sciences                         
Clark Atlanta University
Office: 404-880-8134
Fax: 404-880-8065 


B.S. University of Maryland Eastern Shore
Ph.D. Meharry Medical College
PostDoctoral: Harvard Medical School and Beth Israel Deaconess Medical Center

Research Interest

Our laboratory focuses on mechanisms responsible for cancer cell metastasis at both the cellular and molecular levels.  In this regard, we currently study the involvement of chemokine pathways that induce motility of cancer cells.  The primary objective is to study how the CXCR4/CXCL12 signaling axis may aid in the migration and invasion of foreign tissues under cancerous condition.  This system is studied in prostate and breast cancer cells. 

The following are some of the specific projects in our laboratory:
           ·         The role of tumor suppressors in CXCR4-mediated metastasis.
           ·         The role of cannabinoinds in anti-tumorigenesis and anti-cancinogenesis


Chetram, M.A., Don-Salu-Hewage A.S., and Hinton, C.V. (2011) ROS Enhances CXCR4-mediated Functions through Inactivation of PTEN in Prostate Cancer Cells:Biochemical and Biophysical Research Communications: 410(2):195-200

Chetram, M.A., Odero-Marah, V. and Hinton, C.V. (2010)Loss of PTEN Permits CXCR4-mediated Tumorigenesis through ERK1/2 in Prostate Cancer Cells: Molecular Cancer Research: Jan;9(1):90-102

Chang, M.A., Morgado, M., Warren, C.R., Hinton, C.V., Farruch-Carson, M.C., Delk, N.A.  (2013) p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines.  Prostate: 74(2):149-63

Jones, K.J., Chetram, M.A., Bethea, D.A., Bryant, L.K., Odero-Marah, V. and Hinton, C.V.  (2013) Cysteine (C)-X-C Receptor 4 Regulates NADPH Oxidase-2 During Oxidative Stress in Prostate Cancer Cells.  Cancer Microenvironment: 6(3): 277–288

Don-Salu-Hewage, AS, Chan, SY, McAndrews, KA, Chetram, MA, Dawson, MR, Bethea, DA, Hinton, CV (2013) Cysteine (C)-X-C Receptor 4 Undergoes Transportin 1-Dependent Nuclear Localization and Remains Functional at the Nucleus of Metastatic Prostate Cancer Cells: PLoS One 2013;8(2):e57194 PMID: 23468933

Chetram MA, Bethea DA, Odero-Marah VA, Don-Salu-Hewage AS, Jones KJ, Hinton C.V. (2013) ROS-Mediated Activation of AKT Induces Apoptosis via pVHL in Prostate Cancer Cells: Mol Cell Biochem 376: 63-71, PMID: 23315288